Ammonium tetrathiomolybdate treatment of copper‐associated hepatopathy in dogs

Treatment of Wilson disease with ammonium tetrathiomolybdate: IV. Comparison of tetrathiomolybdate and trientine in a double-blind study of treatment of the neurologic presentation of Wilson disease.

OBJECTIVE To compare tetrathiomolybdate and trientine in treating patients with the neurologic presentation of Wilson disease for the frequency of neurologic worsening, adverse effects, and degree of neurologic recovery. DESIGN A randomized, double-blind, controlled, 2-arm study of 48 patients with the neurologic presentation of Wilson disease. Patients either received 500 mg of trientine hyd...

Hepatopathy in Dogs & Cats, Traditional Acupuncture Therapy

Ammonium tetrathiomolybdate treatment targets the copper transporter ATP7A and enhances sensitivity of breast cancer to cisplatin

Cisplatin is an effective breast cancer drug but resistance often develops over prolonged chemotherapy. Therefore, we performed a candidate approach RNAi screen in combination with cisplatin treatment to identify molecular pathways conferring survival advantages. The screen identified ATP7A as a therapeutic target. ATP7A is a copper ATPase transporter responsible for intercellular movement and ...

The efficacy of IPL and ammonium lactate 14% versus ammonium lactate alone in the treatment of keratosis pilaris

Background: Keratosis rubra pilaris is a common condition with an estimated percentage of 40% involvement in the population. This condition is inherited as an autosomal dominant trait and more commonly involves patients with dry skin. In the current study, we evaluated the efficacy of intense pulsed light (IPL) plus ammonium lactate versus ammonium lactate alone in the treatmen...

modern surgical techniques in treatment of patients with cleft lip & cleft palate

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